Introduction

This chapter is contextual in nature. It provides an overview of the impact of COVID-19, highlighting both the significant number of deaths caused by the pandemic as well as the economic disruption that occurred. Particular attention is paid to the role of digital technologies during the pandemic, which enabled a wide range of activities (e.g. work, education and shopping) to go online. The disruptive impact of COVID-19 is widespread and far-reaching, with the pandemic acting as a 'change agent' expanding and encouraging the greater use of digital technologies. The second half of the chapter presents summaries of the other chapters in the book. In doing so, it illustrates the scope and scale of the impact of COVID-19, the multitude of different challenges it has caused, and how these varied across different regions and contexts, as well as the diversity of reactions to the pandemic. Some of these reactions are technical in nature, while others are commercial and political. The summaries also draw attention to ongoing policy debates, the significance of which has been heightened by the pandemic. © 2023 the authors.

Beyond the pandemic?: Exploring the impact of COVID-19 on telecommunications and the Internet

This book contains an Open Access chapter The COVID-19 pandemic disrupted economies and society globally. In addressing the crisis, the Internet proved incredibly important in enabling many to shift physical work, education, and social activities online and facilitating the tracking of the progress of the pandemic. Beyond the Pandemic? is the first edited collection to concentrate on the dynamic and complex relationship between the Internet and the role it played in responding to the pandemic. Covid-19 accelerated the digital economy transformation, changing the way work, education, and social engagement is organized, potentially permanently. The collection of international scholars who contributed to this volume offer insightful perspectives on how the Internet ecosystem responded and was changed as a consequence of Covid-19;the sectoral consequences of shifting activity online that the Internet enabled for many, but not for all;and the implications for regulatory policies. Given how central digital technologies are to all aspects of business, society, and government, Beyond the Pandemic? is integral to the exploration of the sectoral consequences of the Internet for business managers, policymakers and researchers engaged in planning and study for the digital economy future and planning for future pandemics. © 2023 Jason Whalley, Volker Stocker and William Lehr.

How COVID-19 accelerated the restructuring of UK retail

COVID-19 accelerated change within the UK retail market. It encouraged the growth of online shopping, providing the necessary demand for grocers to invest in their operations, and transformed the economics of their businesses. As innovative new business models emerged, some existing retailers collapsed leading to significant changes on the high street. Landlords were also affected. As some retail tenants struggled to pay their rents, other parts of the sector prospered and sought additional warehouse capacity to cope with rising demand. Not only does this illustrate how different parts of the retail sector faired during COVID-19, but it also demonstrates how the move online has resulted in the emergence of new opportunities. © 2023 the authors.

Beyond the pandemic: Towards a digitally enabled society and economy

Besides the widespread harm and dreadful impact COVID-19 has caused, it brought about change. Interpreting the pandemic as a 'change agent', it is possible to observe how it accelerated the use of digital technologies, facilitating the migration of many activities to the virtual sphere and thus changing the interaction between the physical and virtual worlds. Although the pandemic accelerated the diffusion and adoption of digital technologies, allowing many to avoid or reduce the harms caused by the pandemic, not everyone benefitted to the same extent. The pandemic exacerbated existing digital divides while creating new ones, simultaneously elevating important policy debates regarding digital infrastructure and inclusion policies. © 2023 the authors.

Rural co-working: New network spaces and new opportunities for a smart countryside

Coworking has been a largely urban phenomenon although new initiatives are emerging in rural areas. Rural coworking is partly a response to the growing need for ICT, which is unevenly provided across rural areas, and partly to the social needs of freelancers and home-workers. By combining technological and social functions, coworking spaces can play key roles in the progress of a Smart Countryside, supporting digital, knowledge-based and creative entrepreneurs within rural places, thus reducing the need for extensive commuting and out-migration, particularly among younger and higher-skilled workers. As working practices evolve in the aftermath of Covid-19, these new physical spaces are expected to facilitate new network connections. Castells' Network Society provides a valuable lens through which to investigate how coworking founders and managers promote a mix of internal and external networks that might create new, and superior, entrepreneurial opportunities. The research highlights strategies to promote collaboration as well as methods of adapting to meet new demands from rural workers in a range of rural settings. As an array of different rural coworking models evolve, we also reflect on the importance of inclusivity and identity in determining their relationship with other actors in the local economy. © 2023 The Authors

Coronavirus disease 2019 subphenotypes and differential treatment response to convalescent plasma in critically ill adults: secondary analyses of a randomized clinical trial.

PURPOSE: Benefit from convalescent plasma therapy for coronavirus disease 2019 (COVID-19) has been inconsistent in randomized clinical trials (RCTs) involving critically ill patients. As COVID-19 patients are immunologically heterogeneous, we hypothesized that immunologically similar COVID-19 subphenotypes may differ in their treatment responses to convalescent plasma and explain inconsistent findings between RCTs . METHODS: We tested this hypothesis in a substudy involving 1239 patients, by measuring 26 biomarkers (cytokines, chemokines, endothelial biomarkers) within the randomized, embedded, multifactorial, adaptive platform trial for community-acquired pneumonia (REMAP-CAP) that assigned 2097 critically ill COVID-19 patients to either high-titer convalescent plasma or usual care. Primary outcome was organ support free days at 21 days (OSFD-21) . RESULTS: Unsupervised analyses identified three subphenotypes/endotypes. In contrast to the more homogeneous subphenotype-2 (N = 128 patients, 10.3%; with elevated type i and type ii effector immune responses) and subphenotype-3 (N = 241, 19.5%; with exaggerated inflammation), the subphenotype-1 had variable biomarker patterns (N = 870 patients, 70.2%). Subphenotypes-2, and -3 had worse outcomes, and subphenotype-1 had better outcomes with convalescent plasma therapy compared with usual care (median (IQR). OSFD-21 in convalescent plasma vs usual care was 0 (- 1, 21) vs 10 (- 1, to 21) in subphenotype-2; 1.5 (- 1, 21) vs 12 (- 1, to 21) in suphenotype-3, and 0 (- 1, 21) vs 0 (- 1, to 21) in subphenotype-1 (test for between-subphenotype differences in treatment effects p = 0.008). CONCLUSIONS: We reported three COVID-19 subphenotypes, among critically ill adults, with differential treatment effects to ABO-compatible convalescent plasma therapy. Differences in subphenotype prevalence between RCT populations probably explain inconsistent results with COVID-19 immunotherapies.